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28 March 2024
 
  » pubmed » pmid9027312

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Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death
A M Chinnaiyan ; K O’Rourke ; B R Lane ; V M Dixit ;
Date 21 Feb 1997
Journal Science, 275 (5303), 1122-6
AbstractPrevious genetic studies of the nematode Caenorhabditis elegans identified three important components of the cell death machinery. CED-3 and CED-4 function to kill cells, whereas CED-9 protects cells from death. Here CED-9 and its mammalian homolog Bcl-xL (a member of the Bcl-2 family of cell death regulators) were both found to interact with and inhibit the function of CED-4. In addition, analysis revealed that CED-4 can simultaneously interact with CED-3 and its mammalian counterparts interleukin-1beta-converting enzyme (ICE) and FLICE. Thus, CED-4 plays a central role in the cell death pathway, biochemically linking CED-9 and the Bcl-2 family to CED-3 and the ICE family of pro-apoptotic cysteine proteases.
Source PubMed, pmid9027312
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