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28 March 2024 |
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Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death | A M Chinnaiyan
; K O’Rourke
; B R Lane
; V M Dixit
; | Date: |
21 Feb 1997 | Journal: | Science, 275 (5303), 1122-6 | Abstract: | Previous genetic studies of the nematode Caenorhabditis elegans identified three important components of the cell death machinery. CED-3 and CED-4 function to kill cells, whereas CED-9 protects cells from death. Here CED-9 and its mammalian homolog Bcl-xL (a member of the Bcl-2 family of cell death regulators) were both found to interact with and inhibit the function of CED-4. In addition, analysis revealed that CED-4 can simultaneously interact with CED-3 and its mammalian counterparts interleukin-1beta-converting enzyme (ICE) and FLICE. Thus, CED-4 plays a central role in the cell death pathway, biochemically linking CED-9 and the Bcl-2 family to CED-3 and the ICE family of pro-apoptotic cysteine proteases. | Source: | PubMed, pmid9027312 | Services: | Forum | Review | Favorites |
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