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Evidence for physical and functional association between EMB-5 and LIN-12 in Caenorhabditis elegans | | E J Hubbard
; Q Dong
; I Greenwald
; | | Date: |
5 Jul 1996 | | Journal: | Science, 273 (5271), 112-5 | | Abstract: | The Caenorhabditis elegans LIN-12 and GLP-1 proteins are members of the LIN-12/Notch family of receptors for intercellular signals that specify cell fate. Evidence presented here suggests that the intracellular domains of LIN-12 and GLP-1 interact with the C. elegans EMB-5 protein and that the emb-5 gene functions in the same pathway as the lin-12 and glp-1 genes. EMB-5 is similar in sequence to a yeast protein that controls chromatin structure. Hence, a direct consequence of LIN-12 or GLP-1 activation may be an alteration of chromatin structure that produces changes in transcriptional activity. | | Source: | PubMed, pmid8658178 | | Services: | Forum | Review | Favorites | |
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