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20 April 2024

» pubmed » pmid8560265

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Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent
J Linnen ; J Wages ; Z Y Zhang-Keck ; K E Fry ; K Z Krawczynski ; H Alter ; E Koonin ; M Gallagher ; M Alter ; S Hadziyannis ; P Karayiannis ; K Fung ; Y Nakatsuji ; J W Shih ; L Young ; M Piatak ; C Hoover ; J Fernandez ; S Chen ; J C Zou ; T Morris ; K C Hyams ; S Ismay ; J D Lifson ; G Hess ; S K Foung ; H Thomas ; D Bradley ; H Margolis ; J P Kim ;
Date:	26 Jan 1996
Journal:	Science, 271 (5248), 505-8
Abstract:	An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.
Source:	PubMed, pmid8560265
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