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19 March 2024
 
  » pubmed » pmid7502044

 Article overview


Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine
C C Tsai ; K E Follis ; A Sabo ; T W Beck ; R F Grant ; N Bischofberger ; R E Benveniste ; R Black ;
Date 17 Nov 1995
Journal Science, 270 (5239), 1197-9
AbstractThe efficacy of pre- and postexposure treatment with the antiviral compound (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) was tested against simian immunodeficiency virus (SIV) in macaques as a model for human immunodeficiency virus (HIV). PMPA was administered subcutaneously once daily beginning either 48 hours before, 4 hours after, or 24 hours after virus inoculation. Treatment continued for 4 weeks and the virologic, immunologic, and clinical status of the macaques was monitored for up to 56 weeks. PMPA prevented SIV infection in all macaques without toxicity, whereas all control macaques became infected. These results suggest a potential role for PMPA prophylaxis against early HIV infection in cases of known exposure.
Source PubMed, pmid7502044
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