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25 April 2024

» pubmed » pmid7502043

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Inhibitors of HIV nucleocapsid protein zinc fingers as candidates for the treatment of AIDS
W G Rice ; J G Supko ; L Malspeis ; R W Buckheit ; D Clanton ; M Bu ; L Graham ; C A Schaeffer ; J A Turpin ; J Domagala ; R Gogliotti ; J P Bader ; S M Halliday ; L Coren ; R C Sowder ; L O Arthur ; L E Henderson ;
Date:	17 Nov 1995
Journal:	Science, 270 (5239), 1194-7
Abstract:	Strategies for the treatment of human immunodeficiency virus-type 1 (HIV-1) infection must contend with the obstacle of drug resistance. HIV-1 nucleocapsid protein zinc fingers are prime antiviral targets because they are mutationally intolerant and are required both for acute infection and virion assembly. Nontoxic disulfide-substituted benzamides were identified that attack the zinc fingers, inactivate cell-free virions, inhibit acute and chronic infections, and exhibit broad antiretroviral activity. The compounds were highly synergistic with other antiviral agents, and resistant mutants have not been detected. Zinc finger-reactive compounds may offer an anti-HIV strategy that restricts drug-resistance development.
Source:	PubMed, pmid7502043
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