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19 March 2024
 
  » pubmed » pmid7542404

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CD1-restricted T cell recognition of microbial lipoglycan antigens
P A Sieling ; D Chatterjee ; S A Porcelli ; T I Prigozy ; R J Mazzaccaro ; T Soriano ; B R Bloom ; M B Brenner ; M Kronenberg ; P J Brennan ;
Date 14 Jul 1995
Journal Science, 269 (5221), 227-30
AbstractIt has long been the paradigm that T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be presented to T cells by human CD1b molecules, which are not encoded by the MHC. A major class of microbial antigens associated with pathogenicity are lipoglycans. It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes. Presentation of these lipoglycan antigens required internalization and endosomal acidification. The T cell recognition required mannosides with alpha(1-->2) linkages and a phosphotidylinositol unit. T cells activated by LAM produced interferon gamma and were cytolytic. Thus, an important class of microbial molecules, the lipoglycans, is a part of the universe of foreign antigens recognized by human T cells.
Source PubMed, pmid7542404
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