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CD1-restricted T cell recognition of microbial lipoglycan antigens | P A Sieling
; D Chatterjee
; S A Porcelli
; T I Prigozy
; R J Mazzaccaro
; T Soriano
; B R Bloom
; M B Brenner
; M Kronenberg
; P J Brennan
; | Date: |
14 Jul 1995 | Journal: | Science, 269 (5221), 227-30 | Abstract: | It has long been the paradigm that T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be presented to T cells by human CD1b molecules, which are not encoded by the MHC. A major class of microbial antigens associated with pathogenicity are lipoglycans. It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes. Presentation of these lipoglycan antigens required internalization and endosomal acidification. The T cell recognition required mannosides with alpha(1-->2) linkages and a phosphotidylinositol unit. T cells activated by LAM produced interferon gamma and were cytolytic. Thus, an important class of microbial molecules, the lipoglycans, is a part of the universe of foreign antigens recognized by human T cells. | Source: | PubMed, pmid7542404 | Services: | Forum | Review | Favorites |
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