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29 March 2024
 
  » pubmed » pmid8128250

 Article overview


Long-range cis preference in DNA homology search over the length of a Drosophila chromosome
W R Engels ; C R Preston ; D M Johnson-Schlitz ;
Date 18 Mar 1994
Journal Science, 263 (5153), 1623-5
AbstractP element-induced chromosome breakage on the X chromosome of Drosophila melanogaster was repaired six times more frequently when a homologous template was located anywhere on the X chromosome rather than on an autosome. Cis-trans comparisons confirmed that recombinational repair was more frequent when the interacting sequences were physically connected. These results suggest that the search for homology between the broken ends and a matching template sequence occurs preferentially in the cis configuration. This cis advantage operates over more than 15 megabases of DNA.
Source PubMed, pmid8128250
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