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Article overview
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Long-range cis preference in DNA homology search over the length of a Drosophila chromosome | W R Engels
; C R Preston
; D M Johnson-Schlitz
; | Date: |
18 Mar 1994 | Journal: | Science, 263 (5153), 1623-5 | Abstract: | P element-induced chromosome breakage on the X chromosome of Drosophila melanogaster was repaired six times more frequently when a homologous template was located anywhere on the X chromosome rather than on an autosome. Cis-trans comparisons confirmed that recombinational repair was more frequent when the interacting sequences were physically connected. These results suggest that the search for homology between the broken ends and a matching template sequence occurs preferentially in the cis configuration. This cis advantage operates over more than 15 megabases of DNA. | Source: | PubMed, pmid8128250 | Services: | Forum | Review | Favorites |
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