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25 April 2024 |
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Article overview
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WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant | | D A Haber
; S Park
; S Maheswaran
; C Englert
; G G Re
; D J Hazen-Martin
; D A Sens
; A J Garvin
; | | Date: |
24 Dec 1993 | | Journal: | Science, 262 (5142), 2057-9 | | Abstract: | A human Wilms tumor cell line (RM1) was developed to test the tumor suppressor activity of WT1, a zinc finger transcription factor that is expressed in the developing human kidney and is mutationally inactivated in a subset of Wilms tumors. Transfection of each of four wild-type WT1 isoforms suppressed the growth of RM1 cells. The endogenous WT1 transcript in these cells was devoid of exon 2 sequences, a splicing alteration that was also detected in varying amounts in all Wilms tumors tested but not in normal kidney. Production of this abnormal transcript, which encodes a functionally altered protein, may represent a distinct mechanism for inactivating WT1 in Wilms tumors. | | Source: | PubMed, pmid8266105 | | Services: | Forum | Review | Favorites | |
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