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Induction of type I diabetes by interferon-alpha in transgenic mice | | T A Stewart
; B Hultgren
; X Huang
; S Pitts-Meek
; J Hully
; N J MacLachlan
; | | Date: |
25 Jun 1993 | | Journal: | Science, 260 (5116), 1942-6 | | Abstract: | Type I diabetes is an autoimmune disease involving an interaction between an epigenetic event (possibly a viral infection), the pancreatic beta cells, and the immune system in a genetically susceptible host. The possibility that the type I interferons could mediate this interaction was tested with transgenic mice in which the insulin-producing beta cells expressed an interferon-alpha. These mice developed a hypoinsulinemic diabetes associated with a mixed inflammation centered on the islets. The inflammation and the diabetes were prevented with a neutralizing antibody to the interferon-alpha. Thus, the expression of interferon-alpha by the beta cells could be causal in the development of type I diabetes, which suggests a therapeutic approach to this disease. | | Source: | PubMed, pmid8100367 | | Services: | Forum | Review | Favorites | |
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