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Targeted degradation of c-Fos, but not v-Fos, by a phosphorylation-dependent signal on c-Jun | | A G Papavassiliou
; M Treier
; C Chavrier
; D Bohmann
; | | Date: |
18 Dec 1992 | | Journal: | Science, 258 (5090), 1941-4 | | Abstract: | The proto-oncogene products c-Fos and c-Jun heterodimerize through their leucine zippers to form the AP-1 transcription factor. The transcriptional activity of the heterodimer is regulated by signal-dependent phosphorylation and dephosphorylation events. The stability of c-Fos was found to also be controlled by intracellular signal transduction. In transient expression and in vitro degradation experiments, the stability of c-Fos was decreased when the protein was dimerized with phosphorylated c-Jun. c-Jun protein isolated from phorbol ester-induced cells did not target c-Fos for degradation, which suggests that c-Fos is transiently stabilized after stimulation of cell growth. v-Fos protein, the retroviral counterpart of c-Fos, was not susceptible to degradation targeted by c-Jun. | | Source: | PubMed, pmid1470918 | | Services: | Forum | Review | Favorites | |
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