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29 March 2024 |
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Suppression of tumorigenicity in Wilms tumor by the p15.5-p14 region of chromosome 11 | S F Dowdy
; C L Fasching
; D Araujo
; K M Lai
; E Livanos
; B E Weissman
; E J Stanbridge
; | Date: |
11 Oct 1991 | Journal: | Science, 254 (5029), 293-5 | Abstract: | Wilms tumor has been associated with genomic alterations at both the 11p13 and 11p15 regions. To differentiate between the involvement of these two loci, a chromosome 11 was constructed that had one or the other region deleted, and this chromosome was introduced into the tumorigenic Wilms tumor cell line G401. When assayed for tumor-forming activity in nude mice, the 11p13-deleted, but not the 11p15.5-p14.1-deleted chromosome, retained its ability to suppress tumor formation. These results provide in vivo functional evidence for the existence of a second genetic locus (WT2) involved in suppressing the tumorigenic phenotype of Wilms tumor. | Source: | PubMed, pmid1656527 | Services: | Forum | Review | Favorites |
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