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29 March 2024
 
  » pubmed » pmid1656527

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Suppression of tumorigenicity in Wilms tumor by the p15.5-p14 region of chromosome 11
S F Dowdy ; C L Fasching ; D Araujo ; K M Lai ; E Livanos ; B E Weissman ; E J Stanbridge ;
Date 11 Oct 1991
Journal Science, 254 (5029), 293-5
AbstractWilms tumor has been associated with genomic alterations at both the 11p13 and 11p15 regions. To differentiate between the involvement of these two loci, a chromosome 11 was constructed that had one or the other region deleted, and this chromosome was introduced into the tumorigenic Wilms tumor cell line G401. When assayed for tumor-forming activity in nude mice, the 11p13-deleted, but not the 11p15.5-p14.1-deleted chromosome, retained its ability to suppress tumor formation. These results provide in vivo functional evidence for the existence of a second genetic locus (WT2) involved in suppressing the tumorigenic phenotype of Wilms tumor.
Source PubMed, pmid1656527
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