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Transcriptional repression mediated by the WT1 Wilms tumor gene product | | S L Madden
; D M Cook
; J F Morris
; A Gashler
; V P Sukhatme
; F J Rauscher
; | | Date: |
27 Sep 1991 | | Journal: | Science, 253 (5027), 1550-3 | | Abstract: | The wt1 gene, a putative tumor suppressor gene located at the Wilms tumor (WT) locus on chromosome 11p13, encodes a zinc finger-containing protein that binds to the same DNA sequence as EGR-1, a mitogen-inducible immediate-early gene product that activates transcription. The transcriptional regulatory potential of WT1 has not been demonstrated. In transient transfection assays, the WT1 protein functioned as a repressor of transcription when bound to the EGR-1 site. The repression function was mapped to the glutamine- and proline-rich NH2-terminus of WT1; fusion of this domain to the zinc finger region of EGR-1 converted EGR-1 into a transcriptional repressor. | | Source: | PubMed, pmid1654597 | | Services: | Forum | Review | Favorites | |
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