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26 April 2024 |
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Wilms tumor locus on 11p13 defined by multiple CpG island-associated transcripts | | L Bonetta
; S E Kuehn
; A Huang
; D J Law
; L M Kalikin
; M Koi
; A E Reeve
; B H Brownstein
; H Yeger
; B R Williams
; | | Date: |
16 Nov 1990 | | Journal: | Science, 250 (4983), 994-7 | | Abstract: | Wilms tumor is an embryonal kidney tumor involving complex pathology and genetics. The Wilms tumor locus on chromosome 11p13 is defined by the region of overlap of constitutional and tumor-associated deletions. Chromosome walking and yeast artificial chromosome (YAC) cloning were used to clone and map 850 kilobases of DNA. Nine CpG islands, constituting a "CpG island archipelago," were identified, including three islands that were not apparent by conventional pulsed-field mapping, and thus were at least partially methylated. Three distinct transcriptional units were found closely associated with a CpG island within the boundaries of a homozygous DNA deletion in a Wilms tumor. | | Source: | PubMed, pmid2173146 | | Services: | Forum | Review | Favorites | |
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