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25 April 2024 |
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Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor | | A Huang
; C E Campbell
; L Bonetta
; M S McAndrews-Hill
; S Chilton-MacNeill
; M J Coppes
; D J Law
; A P Feinberg
; H Yeger
; B R Williams
; | | Date: |
16 Nov 1990 | | Journal: | Science, 250 (4983), 991-4 | | Abstract: | The Wilms tumor locus on chromosome 11p13 has been mapped to a region defined by overlapping, tumor-specific deletions. Complementary DNA clones representing transcripts of 2.5 (WIT-1) and 3.5 kb (WIT-2) mapping to this region were isolated from a kidney complementary DNA library. Expression of WIT-1 and WIT-2 was restricted to kidney and spleen. RNase protection revealed divergent transcription of WIT-1 and WIT-2, originating from a DNA region of less than 600 bp. Both transcripts were present at high concentrations in fetal kidney and at much reduced amounts in 5-year-old and adult kidneys. Eleven of 12 Wilms tumors classified as histopathologically heterogeneous exhibited absent or reduced expression of WIT-2, whereas only 4 of 14 histopathologically homogeneous tumors showed reduced expression. These data demonstrate a molecular basis for the pathogenetic heterogeneity in Wilms tumorigenesis. | | Source: | PubMed, pmid2173145 | | Services: | Forum | Review | Favorites | |
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