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19 April 2024 |
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Cleavage of amyloid beta peptide during constitutive processing of its precursor | | F S Esch
; P S Keim
; E C Beattie
; R W Blacher
; A R Culwell
; T Oltersdorf
; D McClure
; P J Ward
; | | Date: |
1 Jun 1990 | | Journal: | Science, 248 (4959), 1122-4 | | Abstract: | The amyloid beta peptide (A beta P) is a small fragment of the much larger, broadly distributed amyloid precursor protein (APP). Abundant A beta P deposition in the brains of patients with Alzheimer’s disease suggests that altered APP processing may represent a key pathogenic event. Direct protein structural analyses showed that constitutive processing in human embryonic kidney 293 cells cleaves APP in the interior of the A beta P, thus preventing A beta P deposition. A deficiency of this processing event may ultimately prove to be the etiological event in Alzheimer’s disease that gives rise to senile plaque formation. | | Source: | PubMed, pmid2111583 | | Services: | Forum | Review | Favorites | |
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