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18 April 2024 |
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Primary structure of the gamma subunit of the DHP-sensitive calcium channel from skeletal muscle | S D Jay
; S B Ellis
; A F McCue
; M E Williams
; T S Vedvick
; M M Harpold
; K P Campbell
; | Date: |
27 Apr 1990 | Journal: | Science, 248 (4954), 490-2 | Abstract: | Affinity-purified, polyclonal antibodies to the gamma subunit of the dihydropyridine (DHP)-sensitive, voltage-dependent calcium channel have been used to isolate complementary DNAs to the rabbit skeletal muscle protein from an expression library. The deduced primary structure indicates that the gamma subunit is a 25,058-dalton protein that contains four transmembrane domains and two N-linked glycosylation sites, consistent with biochemical analyses showing that the gamma subunit is a glycosylated hydrophobic protein. Nucleic acid hybridization studies indicate that there is a 1200-nucleotide transcript in skeletal muscle but not in brain or heart. The gamma subunit may play a role in assembly, modulation, or the structure of the skeletal muscle calcium channel. | Source: | PubMed, pmid2158672 | Services: | Forum | Review | Favorites |
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