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28 March 2024 |
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Article overview
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Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's | M Hatakeyama
; M Tsudo
; S Minamoto
; T Kono
; T Doi
; T Miyata
; M Miyasaka
; T Taniguchi
; | Date: |
5 May 1989 | Journal: | Science, 244 (4904), 551-6 | Abstract: | Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, p70-75) chain. The cDNA encoding the human IL-2R beta chain has now been isolated. The overall primary structure of the IL-2R beta chain shows no apparent homology to other known receptors. Unlike the IL-2R alpha chain, the IL-2R beta chain has a large cytoplasmic region in which a functional domain (or domains) mediating an intracellular signal transduction pathway (or pathways) may be embodied. The cDNA-encoded beta chain binds and internalizes IL-2 when expressed on T lymphoid cells but not fibroblast cells. Furthermore, the cDNA gives rise to the generation of high-affinity IL-2 receptor when co-expressed with the IL-2R alpha chain cDNA. | Source: | PubMed, pmid2785715 | Services: | Forum | Review | Favorites |
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