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29 March 2024 |
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A novel human gene closely related to the abl proto-oncogene | G D Kruh
; C R King
; M H Kraus
; N C Popescu
; S C Amsbaugh
; W O McBride
; S A Aaronson
; | Date: |
19 Dec 1986 | Journal: | Science, 234 (4783), 1545-8 | Abstract: | A DNA sequence related to the abl proto-oncogene was identified in human placenta. Molecular cloning and nucleotide sequence analysis revealed two putative exons whose predicted amino acid sequence was most homologous to the corresponding sequences of c-abl and v-abl but was related to other tyrosine kinase genes as well. The new sequence was localized by in situ hybridization and somatic cell genetic analysis to human chromosome 1q24-25, which differs from the location of any previously identified tyrosine kinase gene. The detection of a novel 12-kb transcript by this gene in human normal and tumor cells establishes it as a new member of the tyrosine kinase family that is closely related to but distinct from c-abl. | Source: | PubMed, pmid3787260 | Services: | Forum | Review | Favorites |
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