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29 March 2024
 
  » pubmed » pmid3787260

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A novel human gene closely related to the abl proto-oncogene
G D Kruh ; C R King ; M H Kraus ; N C Popescu ; S C Amsbaugh ; W O McBride ; S A Aaronson ;
Date 19 Dec 1986
Journal Science, 234 (4783), 1545-8
AbstractA DNA sequence related to the abl proto-oncogene was identified in human placenta. Molecular cloning and nucleotide sequence analysis revealed two putative exons whose predicted amino acid sequence was most homologous to the corresponding sequences of c-abl and v-abl but was related to other tyrosine kinase genes as well. The new sequence was localized by in situ hybridization and somatic cell genetic analysis to human chromosome 1q24-25, which differs from the location of any previously identified tyrosine kinase gene. The detection of a novel 12-kb transcript by this gene in human normal and tumor cells establishes it as a new member of the tyrosine kinase family that is closely related to but distinct from c-abl.
Source PubMed, pmid3787260
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