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28 March 2024 |
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Measurement of single channel currents from cardiac gap junctions | R D Veenstra
; R L DeHaan
; | Date: |
29 Aug 1986 | Journal: | Science, 233 (4767), 972-4 | Abstract: | Cardiac gap junctions consist of arrays of integral membrane proteins joined across the intercellular cleft at points of cell-to-cell contact. These junctional proteins are thought to form pores through which ions can diffuse from cytosol to cytosol. By monitoring whole-cell currents in pairs of embryonic heart cells with two independent patch-clamp circuits, the properties of single gap junction channels have been investigated. These channels had a conductance of about 165 picosiemens and underwent spontaneous openings and closings that were independent of voltage. Channel activity and macroscopic junctional conductance were both decreased by the uncoupling agent 1-octanol. | Source: | PubMed, pmid2426781 | Services: | Forum | Review | Favorites |
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