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19 April 2024 |
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Hu-ets-1 and Hu-ets-2 genes are transposed in acute leukemias with (4;11) and (8;21) translocations | N Sacchi
; D K Watson
; A H Guerts van Kessel
; A Hagemeijer
; J Kersey
; H D Drabkin
; D Patterson
; T S Papas
; | Date: |
24 Jan 1986 | Journal: | Science, 231 (4736), 379-82 | Abstract: | Human probes identifying the cellular homologs of the v-ets gene, Hu-ets-1 and Hu-ets-2, and two panels of rodent-human cell hybrids were used to study specific translocations occurring in acute leukemias. The human ets-1 gene was found to translocate from chromosome 11 to 4 in the t(4;11)(q21;23), a translocation characteristic of a subtype of leukemia that represents the expansion of a myeloid/lymphoid precursor cell. Similarly, the human ets-2 gene was found to translocate from chromosome 21 to chromosome 8 in the t(8;21)(q22;q22), a nonrandom translocation commonly found in patients with acute myeloid leukemia with morphology M2 (AML-M2). Both translocations are associated with expression different from the expression in normal lymphoid cells of ets genes, raising the possibility that these genes play a role in the pathogenesis of these leukemias. | Source: | PubMed, pmid3941901 | Services: | Forum | Review | Favorites |
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