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Article overview
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Z-DNA forms without an alternating purine-pyrimidine sequence in solution | J Feigon
; A H Wang
; G A van der Marel
; J H van Boom
; A Rich
; | Date: |
4 Oct 1985 | Journal: | Science, 230 (4721), 82-4 | Abstract: | Nuclear magnetic resonance spectra (proton and phosphorus-31) and ultraviolet absorption spectra of the DNA decamer d(br5CGbr5CGATbr5CGbr5CG), in which the central two adenine-thymine base pairs are out of order with the rest of the purine-pyrimidine alternation sequence, indicate that under appropriate solvent conditions (high salt and methanol) the molecule undergoes a structural transition from a right-handed B-DNA conformation to a left-handed Z-DNA conformation. Measurements of the two-dimensional nuclear Overhauser effect on the decamer indicate that all of the guanines as well as the two equivalent thymines adopt the syn conformation. | Source: | PubMed, pmid4035359 | Services: | Forum | Review | Favorites |
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