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29 March 2024 |
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Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III | P J Kanki
; M F McLane
; N W King
; N L Letvin
; R D Hunt
; P Sehgal
; M D Daniel
; R C Desrosiers
; M Essex
; | Date: |
7 Jun 1985 | Journal: | Science, 228 (4704), 1199-201 | Abstract: | Human T-lymphotropic virus type III (HTLV-III) is thought to play an etiologic role in the development of the acquired immune deficiency syndrome (AIDS). In this study the serologic characterization of a new simian retrovirus that is related to HTLV-III is described. This new virus, here referred to as STLV-III, was isolated from sick macaques at the New England Regional Primate Research Center. Radioimmunoprecipitation analysis revealed STLV-III-specific proteins of 160, 120, 55, and 24 kilodaltons, all similar in size to the major gag and env proteins of HTLV-III. These antigens were recognized by representative macaque serum samples and human reference serum samples positive for HTLV-III antibodies. Monoclonal antibodies directed to p24, the major core protein of HTLV-III, also immunoprecipitated a 24-kilodalton species in lysates of cells infected with the macaque virus. This HTLV-III-related virus, which naturally infects a nonhuman primate species, may provide a useful model for the study of HTLV-III and the pathogenesis of AIDS. | Source: | PubMed, pmid3873705 | Services: | Forum | Review | Favorites |
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