| | |
| | |
Stat |
Members: 3643 Articles: 2'487'895 Articles rated: 2609
29 March 2024 |
|
| | | |
|
Article overview
| |
|
Molecular structure of troponin C from chicken skeletal muscle at 3-angstrom resolution | M Sundaralingam
; R Bergstrom
; G Strasburg
; S T Rao
; P Roychowdhury
; M Greaser
; B C Wang
; | Date: |
22 Feb 1985 | Journal: | Science, 227 (4689), 945-8 | Abstract: | The x-ray structure of chicken skeletal muscle troponin C (TnC), the Ca2+-binding subunit of the troponin complex, shows that the protein is about 70 angstroms long with an unusual dumbbell shape. The carboxyl and amino domains are separated by a single long alpha helix of about nine turns. Only the two high-affinity Ca2+-Mg2+ sites of the COOH-domain are occupied by metal ions resulting in conformational differences between the COOH- and NH2-domains. These differences are probably important in the triggering of muscle contraction by TnC. Also the structure of TnC is relevant in understanding the function of other calcium-regulated proteins, in particular that of calmodulin because of its strong similarity in amino acid sequence. | Source: | PubMed, pmid3969570 | Services: | Forum | Review | Favorites |
|
|
No review found.
Did you like this article?
Note: answers to reviews or questions about the article must be posted in the forum section.
Authors are not allowed to review their own article. They can use the forum section.
browser claudebot
|
| |
|
|
|
| News, job offers and information for researchers and scientists:
| |