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29 March 2024
 
  » pubmed » pmid3969570

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Molecular structure of troponin C from chicken skeletal muscle at 3-angstrom resolution
M Sundaralingam ; R Bergstrom ; G Strasburg ; S T Rao ; P Roychowdhury ; M Greaser ; B C Wang ;
Date 22 Feb 1985
Journal Science, 227 (4689), 945-8
AbstractThe x-ray structure of chicken skeletal muscle troponin C (TnC), the Ca2+-binding subunit of the troponin complex, shows that the protein is about 70 angstroms long with an unusual dumbbell shape. The carboxyl and amino domains are separated by a single long alpha helix of about nine turns. Only the two high-affinity Ca2+-Mg2+ sites of the COOH-domain are occupied by metal ions resulting in conformational differences between the COOH- and NH2-domains. These differences are probably important in the triggering of muscle contraction by TnC. Also the structure of TnC is relevant in understanding the function of other calcium-regulated proteins, in particular that of calmodulin because of its strong similarity in amino acid sequence.
Source PubMed, pmid3969570
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