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18 April 2024 |
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Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene | | D M Kranz
; H Saito
; C M Disteche
; K Swisshelm
; D Pravtcheva
; F H Ruddle
; H N Eisen
; S Tonegawa
; | | Date: |
22 Feb 1985 | | Journal: | Science, 227 (4689), 941-5 | | Abstract: | Two independent methods were used to identify the mouse chromosomes on which are located two families of immunoglobulin (Ig)-like genes that are rearranged and expressed in T lymphocytes. The genes coding for the alpha subunit of T-cell receptors are on chromosome 14 and the gamma genes, whose function is yet to be determined, are on chromosome 13. Since genes for the T-cell receptor beta chain were previously shown to be on mouse chromosome 6, all three of the Ig-like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B-cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains. The findings do not support earlier contentions that genes for T-cell receptors are linked to the Ig heavy chain locus (mouse chromosome 12) or to the major histocompatibility complex (mouse chromosome 17). | | Source: | PubMed, pmid3918347 | | Services: | Forum | Review | Favorites | |
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