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24 April 2024 |
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Transformation induced by Abelson murine leukemia virus involves production of a polypeptide growth factor | | D R Twardzik
; G J Todaro
; H Marquardt
; F H Reynolds
; J R Stephenson
; | | Date: |
21 May 1982 | | Journal: | Science, 216 (4548), 894-7 | | Abstract: | Rat embryo fibroblasts transformed by Abelson murine leukemia virus (MuLV) produce and release a transforming growth factor (TGF). Production of this factor is correlated with a tyrosine-specific protein kinase that is functionally active and is associated with the major Abelson MuLV gene product, P120. Transformation-defective mutants of Abelson MuLV do not transform cells, do not have their virus coded transforming gene product phosphorylated in tyrosine, and do not induce TGF production. Abelson MuLV-induced TGF morphologically transforms cells in culture, competes with 125I-labeled epidermal growth factor (EGF) for binding to cell receptors, and induces phosphorylation of tyrosine acceptor sites in the 160,000-dalton EGF membrane receptor. After purification to homogeneity, Abelson virus-induced TGF migrates as a single polypeptide with an apparent size of 7400 daltons as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. | | Source: | PubMed, pmid6177040 | | Services: | Forum | Review | Favorites | |
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