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Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor | | M Kasuga
; F A Karlsson
; C R Kahn
; | | Date: |
8 Jan 1982 | | Journal: | Science, 215 (4529), 185-7 | | Abstract: | Cultured human lymphocytes and rat hepatoma cells were labeled with [32P]orthophosphate and the insulin receptor subunits identified by immunoprecipitation and sodium dodecyl sulfate-gel electrophoreses. In both cell types the 95,000-dalton (beta) subunit of the insulin receptor was selectively phosphorylated. Phosphorylation was specifically stimulated by insulin in a dose-dependent fashion after 1 and 15 minutes of hormone treatment, whereas human growth hormone was without effect. This phosphorylation may be a very early event in insulin action. | | Source: | PubMed, pmid7031900 | | Services: | Forum | Review | Favorites | |
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