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16 April 2024 |
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Activation of the transforming potential of a normal cell sequence: a molecular model for oncogenesis | | D G Blair
; M Oskarsson
; T G Wood
; W L McClements
; P J Fischinger
; G G Vande Woude
; | | Date: |
22 May 1981 | | Journal: | Science, 212 (4497), 941-3 | | Abstract: | The molecularly cloned, long terminal repeat (LTR) of the Moloney sarcoma virus (M-MSV) provirus has been covalently linked to c-mos, the cellular homolog of the M-MSV-specific sequence, v-mos. These newly constructed clones lack any M-MSV-derived sequences other than the LTR, but in DNA transfection assays they transform cells as efficiently as cloned subgenomic M-MSV fragments containing both v-mos and LTR. Cells transformed by LTR:c-mos hybrid molecules contain additional copies of mos DNA, and several size classes of polyadenylated RNA’s with sequence homology to mos. The activation of the transforming potential of c-mos by the proviral LTR suggests a model whereby LTR-like elements could activate other normal cell sequences with oncogenic potential. | | Source: | PubMed, pmid7233190 | | Services: | Forum | Review | Favorites | |
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