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29 March 2024
 
  » pubmed » pmid1246630

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Vitamin A: not required for adrenal steroidogenesis in rats
K A Gruber ; L V O’Brien ; R Gerstner ;
Date 6 Feb 1976
Journal Science, 191 (4226), 472-5
AbstractPrevious work supporting the vitamin A dependency of adrenal function in rats neglected to take into account a secondary effect of the deficiency, a decrease in hepatic ascorbic acid biosynthesis. Vitamin A-depleted rats maintained on a diet free of ascorbate had a decrease in the activity of adrenal 3 beta-hydroxysteroid dehydrogenase, and extensive adrenocortical degeneration. The use of an ascorbate supplement prevented the symptoms. The results suggest that previous evidence for direct involvement of vitamin A in steroidogenesis may have been due to the production of a secondary deficiency, a chronic scorbutic condition.
Source PubMed, pmid1246630
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