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Article overview
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Vitamin A: not required for adrenal steroidogenesis in rats | K A Gruber
; L V O’Brien
; R Gerstner
; | Date: |
6 Feb 1976 | Journal: | Science, 191 (4226), 472-5 | Abstract: | Previous work supporting the vitamin A dependency of adrenal function in rats neglected to take into account a secondary effect of the deficiency, a decrease in hepatic ascorbic acid biosynthesis. Vitamin A-depleted rats maintained on a diet free of ascorbate had a decrease in the activity of adrenal 3 beta-hydroxysteroid dehydrogenase, and extensive adrenocortical degeneration. The use of an ascorbate supplement prevented the symptoms. The results suggest that previous evidence for direct involvement of vitamin A in steroidogenesis may have been due to the production of a secondary deficiency, a chronic scorbutic condition. | Source: | PubMed, pmid1246630 | Services: | Forum | Review | Favorites |
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