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28 March 2024
 
  » pubmed » pmid5917091

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Dealkylation and loss of capacity for reactivation of cholinesterase inhibited by sarin
L W Harris ; J H Fleisher ; J Clark ; W J Cliff ;
Date 21 Oct 1966
Journal Science, 154 (747), 404-7
AbstractInhibition of rat brain acetylcholinesterase by (32)P-sarin in vivo results initially in (32)P-isopropylmethylphosphonylated enzyme. The percentage of inhibited enzyme that could not be reactivated by pyridinium aldoxime methochloride (aged enzyme) approximated the amount of radioactivity identified as (32)P-methylphosphonate. The (32)P-isopropyl methylphosphonate not released fromthe inhibited enzyme by the oxime accounted for 51 +/- 10 percent ( standard deviation) of the radioactivity fixed to brain tissue. It showed no correlation with aging and was probably bound to sites other than acetylcholinesterase.
Source PubMed, pmid5917091
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