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19 April 2024

» pubmed » pmid15783309

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Real-time microbe detection based on director distortions around growing immune complexes in lyotropic chromonic liquid crystals
S V Shiyanovskii ; T Schneider ; I I Smalyukh ; T Ishikawa ; G D Niehaus ; K J Doane ; C J Woolverton ; O D Lavrentovich ;
Date:	31 Jan 2005
Journal:	Phys Rev E, 71 (2 Pt 1), 020702
Abstract:	We describe director distortions in the nematic liquid crystal (LC) caused by a spherical particle with tangential surface orientation of the director and show that light transmittance through the distorted region is a steep function of the particle’s size. The effect allows us to propose a real-time microbial sensor based on a nontoxic lyotropic chromonic LC (LCLC) that detects and amplifies the presence of immune complexes. A cassette is filled with LCLC, antibody, and antigen-bearing particles. Small and isolated particles cause no macroscopic distortions of the LCLC. Upon antibody-antigen binding, the growing immune complexes distort the director and cause detectable optical transmittance between crossed polarizers.
Source:	PubMed, pmid15783309
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