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28 March 2024
 
  » arxiv » cond-mat/0212452

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A Simple Kinetic Model Describes the Processivity of Myosin-V
Anatoly B. Kolomeisky ; Michael E. Fisher ;
Date 18 Dec 2002
Subject Statistical Mechanics; Soft Condensed Matter; Subcellular Processes | cond-mat.stat-mech cond-mat.soft q-bio.SC
AbstractMyosin-V is a motor protein responsible for organelle and vesicle transport in cells. Recent single-molecule experiments have shown that it is an efficient processive motor that walks along actin filaments taking steps of mean size close to 36 nm. A theoretical study of myosin-V motility is presented following an approach used successfully to analyze the dynamics of conventional kinesin but also taking some account of step-size variations. Much of the present experimental data for myosin-V can be well described by a two-state chemical kinetic model with three load-dependent rates. In addition, the analysis predicts the variation of the mean velocity and of the randomness -- a quantitative measure of the stochastic deviations from uniform, constant-speed motion -- with ATP concentration under both resisting and assisting loads, and indicates a {it sub}step of size $d_{0} simeq$ 13-14 nm (from the ATP-binding site) that appears to accord with independent observations.
Source arXiv, cond-mat/0212452
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