|
| | | | |
| | | |
| Stat |
Members: 3645
Articles: 2'504'928
Articles rated: 2609
25 April 2024 |
|
| | | | |
|
Article overview
| |
|
|
Steps and bumps: precision extraction of discrete states of molecular machines using physically-based, high-throughput time series analysis | | Max A. Little
; Bradley C. Steel
; Fan Bai
; Yoshiyuki Sowa
; Thomas Bilyard
; David M. Mueller
; Richard M. Berry
; Nick S. Jones
; | | Date: |
Thu, 8 Apr 2010 03:28:15 GMT (1803kb) | | Abstract: | We report new statistical time-series analysis tools providing significant
improvements in the rapid, precision extraction of discrete state dynamics from
large databases of experimental observations of molecular machines. By building
physical knowledge and statistical innovations into analysis tools, we
demonstrate new techniques for recovering discrete state transitions buried in
highly correlated molecular noise. We demonstrate the effectiveness of our
approach on simulated and real examples of step-like rotation of the bacterial
flagellar motor and the F1-ATPase enzyme. We show that our method can clearly
identify molecular steps, symmetries and cascaded processes that are too weak
for existing algorithms to detect, and can do so much faster than existing
algorithms. Our techniques represent a major advance in the drive towards
automated, precision, highthroughput studies of molecular machine dynamics.
Modular, open-source software that implements these techniques is provided at
this http URL | | Source: | arXiv, 1004.1234 | | Services: | Forum | Review | PDF | Favorites | |
|
|
No review found.
Did you like this article?
Note: answers to reviews or questions about the article must be posted in the forum section.
Authors are not allowed to review their own article. They can use the forum section.
browser Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)
|
| |
|
|
|
|
News, job offers and information for researchers and scientists:
| |
REGISTER