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Statistics of reversible bond dynamics observed in force-clamp spectroscopy | | Gregor Diezemann
; Thomas Schlesier
; Burkhard Geil
; Andreas Janshoff
; | | Date: |
10 May 2010 | | Abstract: | We present a detailed analysis of two-state trajectories obtained in
force-clamp spectroscopy (FCS) on reversibly bonded systems. FCS offers the
unique possibility to vary the equilibrium constant in two-state kinetics, for
instance the unfolding and refolding of biomolecules, over a huge range due to
the force dependence of the respective rates. We discuss two different kinds of
counting statistics, the event-counting usually employed in the statistical
analysis of two-state kinetics and additionally a so-called cycle-counting.
While in the former case all transitions are counted cycle-counting means that
we focus on one type of transitions. This might be advantageous in particular
if the equilibrium constant is much larger or much smaller than unity because
in these situations the temporal resolution might not allow for an
event-counting analysis. We show that for complex systems exhibiting dynamic
disorder not only the detection of deviations from Markovian behavior is
possible but also the determination of the average life-time of the disorder
should be feasible in favorable cases. | | Source: | arXiv, 1005.1590 | | Services: | Forum | Review | PDF | Favorites | |
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