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Origins of Chevron Rollovers in Non-Two-State Protein Folding Kinetics | | Huseyin Kaya
; Hue Sun Chan
; | | Date: |
14 Feb 2003 | | Journal: | Physical Review Letters 90, 258104 (2003). | | Subject: | Soft Condensed Matter | cond-mat.soft q-bio | | Abstract: | Chevron rollovers of some proteins imply that their logarithmic folding rates are nonlinear in native stability. This is predicted by lattice and continuum G=o models to arise from diminished accessibilities of the ground state from transiently populated compact conformations under strongly native conditions. Despite these models’ native-centric interactions, the slowdown is due partly to kinetic trapping caused by some of the folding intermediates’ nonnative topologies. Notably, simple two-state folding kinetics of small single-domain proteins are not reproduced by common G=o-like schemes. | | Source: | arXiv, cond-mat/0302305 | | Other source: | [GID 922778] pmid12857173 | | Services: | Forum | Review | PDF | Favorites | |
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