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Preferential attachment in the protein network evolution | | Eli Eisenberg
; Erez Y. Levanon
; | | Date: |
23 Mar 2003 | | Journal: | Phys. Rev. Lett. 91, 138701 (2003) . DOI: 10.1103/PhysRevLett.91.138701 | | Subject: | Statistical Mechanics; Soft Condensed Matter; Molecular Networks | cond-mat.stat-mech cond-mat.soft q-bio.MN | | Abstract: | The Saccharomyces cerevisiae protein-protein interaction map, as well as many natural and man-made networks, shares the scale-free topology. The preferential attachment model was suggested as a generic network evolution model that yields this universal topology. However, it is not clear that the model assumptions hold for the protein interaction network. Using a cross genome comparison we show that (a) the older a protein, the better connected it is, and (b) The number of interactions a protein gains during its evolution is proportional to its connectivity. Therefore, preferential attachment governs the protein network evolution. The evolutionary mechanism leading to such preference and some implications are discussed. | | Source: | arXiv, cond-mat/0303490 | | Other source: | [GID 1068055] pmid14525344 | | Services: | Forum | Review | PDF | Favorites | |
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