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Article overview
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A stochastic microscopic model for the dynamics of antigenic variation | | Gustavo Guerberoff
; Fernando Alvarez-Valin
; | | Date: |
8 Nov 2013 | | Abstract: | We present a novel model that describes the within-host evolutionary dynamics
of parasites undergoing antigenic variation. The approach uses a multi-type
branching process with two types of entities defined according to their
relationship with the immune system: clans of resistant parasitic cells (i.e.
groups of cells sharing the same antigen not yet recognized by the immune
system) that may become sensitive, and individual sensitive cells that can
acquire a new resistance thus giving rise to the emergence of a new clan. The
simplicity of the model allows analytical treatment to determine the
subcritical and supercritical regimes in the space of parameters. By
incorporating a density-dependent mechanism the model is able to capture
additional relevant features observed in experimental data, such as the
characteristic parasitemia waves. In summary our approach provides a new
general framework to address the dynamics of antigenic variation which can be
easily adapted to cope with broader and more complex situations. | | Source: | arXiv, 1311.1861 | | Services: | Forum | Review | PDF | Favorites | |
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