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19 April 2024

» arxiv » 1311.3236

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The genomic landscape of meiotic crossovers and gene conversions in Arabidopsis thaliana
Erik Wijnker ; Geo Velikkakam James ; Jia Ding ; Frank Becker ; Jonas R. Klasen ; Vimal Rawat ; Beth A. Rowan ; Daniel F. de Jong ; C. Bastiaan de Snoo ; Luis Zapata ; Bruno Huettel ; Hans de Jong ; Stephan Ossowski ; Detlef Weigel ; Maarten Koornneef ; Joost J.B. Keurentjes ; Korbinian Schneeberger ;
Date:	13 Nov 2013
Abstract:	Knowledge of the exact distribution of meiotic crossovers (COs) and gene conversions (GCs) is essential for understanding many aspects of population genetics and evolution, from haplotype structure and long-distance genetic linkage to the generation of new allelic variants of genes. To this end, we resequenced the four products of 13 meiotic tetrads along with 10 doubled haploids derived from Arabidopsis thaliana hybrids. GC detection through short reads has previously been confounded by genomic rearrangements. Rigid filtering for misaligned reads allowed GC identification at high accuracy and revealed an ~80-kb transposition, which undergoes copy-number changes mediated by meiotic recombination. Non-crossover associated GCs were extremely rare most likely due to their short average length of ~25-50 bp, which is significantly shorter than the length of CO associated GCs. Overall, recombination preferentially targeted non-methylated nucleosome-free regions at gene promoters, which showed significant enrichment of two sequence motifs.
Source:	arXiv, 1311.3236
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