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Understanding genomic alterations in cancer genomes using an integrative network approach | | Edwin Wang
; | | Date: |
10 Sep 2014 | | Abstract: | In recent years, cancer genome sequencing and other high-throughput studies
of cancer genomes have generated many notable discoveries. In this review,
Novel genomic alteration mechanisms, such as chromothripsis (chromosomal
crisis) and kataegis (mutation storms), and their implications for cancer are
discussed. Genomic alterations spur cancer genome evolution. Thus, the
relationship between cancer clonal evolution and cancer stems cells is
commented. The key question in cancer biology concerns how these genomic
alterations support cancer development and metastasis in the context of
biological functioning. Thus far, efforts such as pathway analysis have
improved the understanding of the functional contributions of genetic mutations
and DNA copy number variations to cancer development, progression and
metastasis. However, the known pathways correspond to a small fraction,
plausibly 5-10%, of somatic mutations and genes with an altered copy number. To
develop a comprehensive understanding of the function of these genomic
alterations in cancer, an integrative network framework is proposed and
discussed. Finally, the challenges and the directions of studying cancer omic
data using an integrative network approach are commented. | | Source: | arXiv, 1409.3263 | | Services: | Forum | Review | PDF | Favorites | |
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