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19 April 2024 |
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Article overview
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Disrupting the wall accumulation of human sperm cells by artificial corrugation | | H.A. Guidobaldi
; Y. Jeyaram
; C.A. Condat
; M. Oviedo
; I. Berdakin
; V.V. Moshchalkov
; L.C. Giojalas
; A.V. Silhanek
; V.I. Marconi
; | | Date: |
7 Jan 2015 | | Abstract: | Many self-propelled microorganisms are attracted to surfaces. This makes
their dynamics in restricted geometries very different from that observed in
the bulk. Swimming along walls is beneficial for directing and sorting cells,
but may be detrimental if homogeneous populations are desired, such as in
counting microchambers. In this work, we characterize the motion of human sperm
cells $sim$60$mu$m long, strongly confined to $sim$20$mu$m shallow
chambers. We investigate the nature of the cell trajectories between the
confining surfaces and their accumulation near the borders. Observed cell
trajectories are composed of a succession of quasi-circular and quasi-linear
segments. This suggests that the cells follow a path of intermittent trappings
near the top and bottom surfaces separated by stretches of quasi-free motion in
between the two surfaces. We show that the introduction of artificial
petal-shaped corrugation in the lateral boundaries limits the accumulation near
the borders and contributes to increase the concentration in the chamber
interior. The steady state limit is achieved over times of the order of
minutes, which agrees well with a theoretical estimate based on the assumption
that the cell mean-square displacement is largely due to the quasi-linear
segments. Pure quasi-circular trajectories would require several hours to
stabilize. Our predictions also indicate that stabilization proceeds 2.5 times
faster in the corrugated chambers than in the non-corrugated ones, which is
another practical reason to prefer the former for microfluidic applications in
biomedicine. | | Source: | arXiv, 1501.1508 | | Services: | Forum | Review | PDF | Favorites | |
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