Collisions between prolate uranium nuclei are used to study how particle
production and azimuthal anisotropies depend on initial geometry in heavy-ion
collisions. We report the two- and four-particle cumulants, $v_2{2}$ and
$v_2{4}$, for charged hadrons from U+U collisions at $sqrt{s_{
m NN}}$ =
193 GeV and Au+Au collisions at $sqrt{s_{
m NN}}$ = 200 GeV. Nearly fully
overlapping collisions are selected based on the amount of energy deposited by
spectators in the STAR Zero Degree Calorimeters (ZDCs). Within this sample, the
observed dependence of $v_2{2}$ on multiplicity demonstrates that ZDC
information combined with multiplicity can preferentially select different
overlap configurations in U+U collisions. An initial-state model with gluon
saturation describes the slope of $v_2{2}$ as a function of multiplicity in
central collisions better than one based on Glauber with a two-component
multiplicity model.
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