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16 April 2024 |
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Noise expands the response range of the Bacillus subtilis competence circuit | | Andrew Mugler
; Mark Kittisopikul
; Luke Hayden
; Jintao Liu
; Chris H. Wiggins
; Gurol M. Suel
; Aleksandra M. Walczak
; | | Date: |
30 Aug 2015 | | Abstract: | Gene regulatory circuits must contend with intrinsic noise that arises due to
finite numbers of proteins. While some circuits act to reduce this noise,
others appear to exploit it. A striking example is the competence circuit in
Bacillus subtilis, which exhibits much larger noise in the duration of its
competence events than a synthetically constructed analog that performs the
same function. Here, using stochastic modeling and fluorescence microscopy, we
show that this larger noise allows cells to exit terminal phenotypic states,
which expands the range of stress levels to which cells are responsive and
leads to phenotypic heterogeneity at the population level. This is an important
example of how noise confers a functional benefit in a genetic decision-making
circuit. | | Source: | arXiv, 1508.7571 | | Services: | Forum | Review | PDF | Favorites | |
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