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Article overview
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Active remodeling of chromatin and implications for in-vivo folding | | N. Ramakrishnan
; Kripa Gowrishankar
; Lakshmi Kuttippurathu
; P. B. Sunil Kumar
; Madan Rao
; | | Date: |
14 Oct 2015 | | Abstract: | Recent high resolution experiments have provided a quantitative description
of the statistical properties of interphase chromatin at large scales. These
findings have stimulated a search for generic physical interactions that give
rise to such specific statistical conformations. Here, we show that an active
chromatin model of in-vivo folding, based on the interplay between polymer
elasticity, confinement, topological constraints and active stresses arising
from the (un)binding of ATP-dependent chromatin-remodeling proteins gives rise
to steady state conformations consistent with these experiments. Our results
lead us to conjecture that the chromatin conformation resulting from this
active folding optimizes information storage by co-locating gene loci which
share transcription resources. | | Source: | arXiv, 1510.4157 | | Services: | Forum | Review | PDF | Favorites | |
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