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20 April 2024

» arxiv » math.OC/0311357

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Optimal length and signal amplification in weakly activated signal transduction cascades
Madalena Chaves ; Eduardo D. Sontag ; Robert J. Dinerstein ;
Date:	20 Nov 2003
Subject:	Optimization and Control; Molecular Networks MSC-class: 93D25, 93B99, 92C99 \| math.OC q-bio.MN
Abstract:	Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system, provide natural measures for the propagation of the input signal down the cascade and for the characterization of the final outcome. The most efficient design of a cascade for generating sharp signals, is obtained by choosing all the off rates equal, and a ``universal’’ finite optimal length.
Source:	arXiv, math.OC/0311357
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