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Universal thermodynamic bounds on nonequilibrium response with biochemical applications | | Jeremy A. Owen
; Todd R. Gingrich
; Jordan M. Horowitz
; | | Date: |
17 May 2019 | | Abstract: | One of the basic characteristics of any physical system is its response to
small perturbations. For instance, response is used to quantify material
properties--such as conductivity and viscoelasticity--the sensing capability of
cells, and the accuracy of biomolecular processes. Near thermodynamic
equilibrium, response is completely determined by the nature of spontaneous
fluctuations, according to the fluctuation-dissipation theorem (FDT). This deep
connection forms the basis of powerful experimental techniques, but also
implies that highly-responsive equilibrium devices are always plagued by noise.
In this work, we present equalities and inequalities--akin to the FDT but valid
arbitrarily far from equilibrium--that link response to the strength of
nonequilibrium driving. Our results open new possibilities to experimentally
characterize away-from-equilibrium response and suggest design principles for
high-sensitivity, low-noise devices. As illustrations, we show how our results
rationalize the energetic requirements of biochemical switches and kinetic
proofreading. | | Source: | arXiv, 1905.7449 | | Services: | Forum | Review | PDF | Favorites | |
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