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29 March 2024
 
  » arxiv » 2004.0950

 Article overview


lambda DNA through a plasmonic nanopore What can be detected by means of Surface Enhanced Raman Scattering?
Aliaksandr Hubarevich ; Jian-An Huang ; Giorgia Giovannini ; Andrea Schirato ; Yingqi Zhao ; Nicolò Maccaferri ; Francesco De Angelis ; Alessandro Alabastri ; Denis Garoli ;
Date 2 Apr 2020
AbstractEngineered electromagnetic fields in plasmonic nanopores enable enhanced optical detection and their use in single molecule sequencing. Here, a plasmonic nanopore prepared in a thick nanoporous film is used to investigate the interaction between the metal and a long-chain double strand DNA molecule. We discuss how the matrix of nanoporous metal can interact with the molecule thanks to: i) transient aspecific interactions between the porous surface and DNA and ii) optical forces exerted by the localized field in a metallic nanostructure. A duration of interaction up to tens of milliseconds enables to collect high signal-to-noise Raman vibrations allowing an easy label-free reading of information from the DNA molecule. Moreover, in order to further increase the event of detection rate, we tested a polymeric porous hydrogel placed beneath the solid-state membrane. This approach enables a slowdown of the molecule diffusion, thus increasing the number of detected interactions by a factor of about 20.
Source arXiv, 2004.0950
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