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Article overview
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Catchbond mediated oscillations in motor-microtubule complexes | Sougata Guha
; MIthun K. Mitra
; Ignacio Pagonabarraga
; Sudipto Muhuri
; | Date: |
10 May 2020 | Abstract: | The activity of motors along with passive crosslinkers play a vital role in
maintaining the integrity of the mitotic spindle structure and in generating
spontaneous oscillations. While the structural features and properties of the
individual motors are well characterized, their implications on the functional
behaviour of motor-microtubule complexes is more involved. We show that the
catchbond behaviour of individual dynein motors manifests as a generic
mechanism of generating spontaneous oscillations in such complexes. The results
reported here elucidate the central role of catchbond mediated mechanism in
fashioning a distinctive stability behaviour and oscillations in
motor-microtubule complexes, such as mitotic spindles. | Source: | arXiv, 2005.4600 | Services: | Forum | Review | PDF | Favorites |
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