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To a Problem of Not Increasing Dynamic Compliance at Asthma Patients with Ventilating Disorders after Berotec Inhalation | | Konstantin F. Tetenev
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11 Feb 2004 | | Subject: | Tissues and Organs | q-bio.TO | | Abstract: | The purpose of research was to check up the influence of decrease of nonequality of ventilating (after bronchodilator (berotec) inhalation (BI)) on the magnitude of dynamic compliance of lungs (Cdyn) at asthma patients with ventilating infringements. Methods and materials: 20 patients (with 2 and 3 degrees of ventilating infringements (VC<73%, FEV1<51%, MVV<56%), without restrictive disease of lungs, suffering from bronchial asthma were studied before and after BI by plotting volume, rate flow, against the transpulmonare pressure. About the change of nonequality of ventilating we consider by the change after BI of Cdyn, Cdyn at once after flow interruption (Cdyn1), tissue resistance at inhalation (Rti in) and exhalation (Rti ex), parameters of ventilating and general parameters of respiratory mechanics. Results: the parameters of ventilating were improved (P < 0,05). General parameters of respiratory mechanics also improved. Rti in and Rti ex are made 0,48+0,16; 1,05+0,25 kPa/l/s before BI and decreased 0,09+0,04; 0,28+0,09 kPa/l/s after BI (P < 0,05; P < 0,05). But Cdyn and Cdyn1 are not changed after BI. Conclusions: 1. The decrease of ventilation nonequality and tissue friction after BI do not influence on the initially reduced dynamic compliance of lungs at asthma patients without any restrictive diseases of lungs. 2. The cause of not increasing of dynamic compliance after BI probably due by changes in elastic component of parenchyma of lungs, insensitive to berotec. | | Source: | arXiv, q-bio.TO/0402025 | | Services: | Forum | Review | PDF | Favorites | |
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