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28 March 2024
 
  » arxiv » q-bio.QM/0406002

 Article overview


Open Mass Spectrometry Search Algorithm
Lewis Y. Geer ; Sanford P. Markey ; Jeffrey A. Kowalak ; Lukas Wagner ; Ming Xu ; Dawn M. Maynard ; Xiaoyu Yang ; Wenyao Shi ; Stephen H. Bryant ;
Date 1 Jun 2004
Subject Quantitative Methods | q-bio.QM
AbstractLarge numbers of MS/MS peptide spectra generated in proteomics experiments require efficient, sensitive and specific algorithms for peptide identification. In the Open Mass Spectrometry Search Algorithm [OMSSA], specificity is calculated by a classic probability score using an explicit model for matching experimental spectra to sequences. At default thresholds, OMSSA matches more spectra from a standard protein cocktail than a comparable algorithm. OMSSA is designed to be faster than published algorithms in searching large MS/MS datasets.
Source arXiv, q-bio.QM/0406002
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