We report three searches for high energy neutrino emission from astrophysical
objects using data recorded with IceCube between 2011 and 2020. Improvements
over previous work include new neutrino reconstruction and data calibration
methods. In one search, the positions of 110 a priori selected gamma-ray
sources were analyzed individually for a possible surplus of neutrinos over
atmospheric and cosmic background expectations. We found an excess of
$79_{-20}^{+22}$ neutrinos associated with the nearby active galaxy NGC 1068 at
a significance of 4.2$,sigma$. The excess, which is spatially consistent with
the direction of the strongest clustering of neutrinos in the Northern Sky, is
interpreted as direct evidence of TeV neutrino emission from a nearby active
galaxy. The inferred flux exceeds the potential TeV gamma-ray flux by at least
one order of magnitude.
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