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Electrophoresis of DNA on a disordered two-dimensional substrate | | C.J. Olson Reichhardt
; C. Reichhardt
; | | Date: |
20 Mar 2005 | | Subject: | Soft Condensed Matter | cond-mat.soft | | Abstract: | We propose a new method for electrophoretic separation of DNA in which adsorbed polymers are driven over a disordered two-dimensional substrate which contains attractive sites for the polymers. Using simulations of a model for long polymer chains, we show that the mobility increases with polymer length, in contrast to gel electrophoresis techniques, and that separation can be achieved for a range of length scales. We demonstrate that the separation mechanism relies on steric interactions between polymer segments. | | Source: | arXiv, cond-mat/0503506 | | Services: | Forum | Review | PDF | Favorites | |
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